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Alterations in lipid metabolism due to a protein-restricted diet in rats during gestation and/or lactation

Abstract

Perinatal malnutrition not only affects fetal and neonatal growth, but also the health of offspring in adulthood, as suggested by the concept of metabolic programming. The impact of maternal protein malnutrition on the metabolism of offspring is demonstrated with the current data. One group of pregnant/lactating female rats was fed with an isocaloric diet having normal protein content. Three other groups were provided 50% of this protein level during pregnancy and/or lactation. The growth and metabolic state of the offspring was monitored. Determination was made of the expression of genes regulating lipid metabolism, including SREBP-1c and SIRT-1 in liver and retroperitoneal adipose tissue. Blood cholesterol and triglycerides were higher in adult offspring (at 110 days of age) undergoing a protein-restricted than a normal diet. Protein restriction likely leads to inadequate detection of glucose levels, suggested by the reduced expression of the gene for GCK, the sensor of glucose in the liver. The effects of a protein-restricted diet were highly dependent on the window in which this limitation occurred. There was a more adverse effect when rats underwent protein restriction during gestation than lactation, producing lower body weight and alterations in lipid metabolism in adult offspring.

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Publication details

The article was accepted on 05 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7FO01513E
Citation: Food Funct., 2017, Accepted Manuscript
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    Alterations in lipid metabolism due to a protein-restricted diet in rats during gestation and/or lactation

    C. T. Sosa-Larios, A. Miliar-García, L. A. Reyes-Castro, L. S. Morimoto and M. E. JARAMILLO-FLORES, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01513E

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