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Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of Sirt1/NF-κB signaling pathway

Abstract

Asiatic acid, a triterpenoid derived from Centella asiatica, has been found to exhibit multiple bioactivities. In this study, we investigated the effects of asiatic acid on lipopolysaccharide (LPS)-induced neuroinflammation and explored the mechanism of its action in BV2 microglia. We found that asiatic acid (0.1 to 100 μM) treatment significantly attenuated nitric oxide (NO) production and inhibited inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner following LPS exposure. Asiatic acid reduced LPS-induced expression and secretion of inflammatory cytokines, including tumor necrosis factor factor-α (TNF-α), interleukin -1β (IL-1β) and interleukin-6 (IL-6) in BV2 cells. In addition, asiatic acid enhanced Sirt1 expression, reduced NF-κB p65 acetylation, and suppressed NF-κB activation after LPS stimulation. However, EX-527, an inhibitor of Sirt1, abolished the inhibitory effects of asiatic acid on LPS-stimulated microglia activation. These findings suggest that asiatic acid prevents LPS-induced neuroinflammation via regulating Sirt1/NF-κB signaling pathway.

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Publication details

The article was received on 18 Sep 2017, accepted on 26 Dec 2017 and first published on 27 Dec 2017


Article type: Paper
DOI: 10.1039/C7FO01442B
Citation: Food Funct., 2017, Accepted Manuscript
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    Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of Sirt1/NF-κB signaling pathway

    Y. Qian, Z. Xin, Y. Lv, Z. Wang, L. Zuo, X. Huang, Y. Li and H. Xin, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01442B

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