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Combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota


Resveratrol and quercetin, widely found in foods and vegetables, are plant polyphenols reported to have a wide range of biological activities. Despite their limited bioavailabilities, both of resveratrol and quercetin were known to exhibit anti-inflammation and anti-obesity effects. We hypothesized that gut microbiota may be as a potential target for resveratrol and quercetin to prevent the development of obesity. The aim of this research was to confirm whether the combination of quercetin and resveratrol (CQR) could restore the gut microbiota dysbiosis induced by high-fat diet (HFD). In this study, Wistar rats were divided into three groups: a normal diet (ND) group, a HFD group and a CQR group. The CQR group was treated with HFD and administrated with the combination of quercetin [30 mg/kg body weight (BW)/day] and resveratrol [15 mg/kg body weight (BW)/day] by oral gavage. As a result, CQR reduced body weight gain, energy intake and visceral (epididymal, perirenal) adipose tissue weight. Moreover, CQR also reduced serum lipids, attenuated serum inflammatory markers [interleukin (IL)-6, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1)] and reversed serum biochemical parameters (adiponectin, insulin, leptin, etc.). Importantly, our results demonstrated that CQR could modulate gut microbiota composition. 16S rRNA gene sequencing revealed that CQR had impact on gut microbiota, decreasing the Firmicutes (P < 0.05) and the proportion of Firmicutes to Bacteroidetes (P = 0.052). CQR also significantly inhibited the relative abundance of Desulfovibrionaceae (P < 0.01), Acidaminococcaceae (P < 0.05), Coriobacteriaceae (P < 0.05), Bilophila (P < 0.05), Lachnoclostridium (P < 0.001) and its genus Lachnospiraceae (P < 0.05), which were reported potentially related to diet-induced obesity. Moreover, compared with the HFD group, the relative abundance of Bacteroidales_S24-7_group (P < 0.01), Christensenellaceae (P < 0.001), Akkermansia (P < 0.01), Ruminococcaceae (P < 0.01) and its genera Ruminococcaceae_UCG-014 (P < 0.01), Ruminococcaceae_UCG-005 (P < 0.01), which were reported to have effect of relieving HFD-induced obesity, were markedly increased in the CQR group. Overall, our results indicated that administration of CQR may have beneficial effects on ameliorating HFD-induced obesity and lessening HFD-induced gut microbiota dysbiosis.

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Publication details

The article was received on 06 Sep 2017, accepted on 26 Oct 2017 and first published on 01 Nov 2017

Article type: Paper
DOI: 10.1039/C7FO01383C
Citation: Food Funct., 2017, Accepted Manuscript
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    Combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota

    L. Zhao, Q. Zhang, W. Ma, F. Tian, H. Shen and M. Zhou, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01383C

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