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Profiling polyphenols composition by HPLC-DAD-ESI/MSn and antibacterial activity of infusion preparations obtained from four medicinal plants

Abstract

Infusions of Thymus pallescens Noë, Saccocalyx satureioides Coss. et Dur., Ptychotis verticillata Briq. and Limoniastrum guyonianum Boiss. have been used as medicinal remedies for many diseases in the Algerian folk medicine. These species have also been well documented as rich sources of phytochemicals, such as phenolic compounds with wide diversified chemical structures, which results in far-ranging biological activities. Thus, the phenolic compounds profile of the aqueous extracts, obtained by infusing, of the mentioned species was obtained by HPLC-DAD-ESI/MS, and their antibacterial activity was evaluated against clinical isolates. Several phenolic acids were identified and quantified, particularly caffeic acid derivatives along with glycosylated flavonoids. T. pallescens and S. satureioides contain 13 phenolic compounds, where rosmarinic acid was the most abundant phenolic acid present, while L. guyonianum presented myricetin-3-O-glucoside and myricetin-O-rhamnoside as the main compounds among the eight detected molecules. P. verticillata presented a profile of ten phenolic compounds, where 5-O-caffeoylquinic acid was the most abundant phenolic acid, followed by the flavone luteolin-3-O-glucoside. Antibacterial activity of the infusions ranged between 2.5 and 20 mg/mL (MIC values), and L. guyonianum showed the highest activity against all the tested bacteria, being Staphylococcus aureus and Pseudomonas aeruginosa the most sensitive and resistant strains, respectively. Thus, the studied plant species are sources of natural antibacterial substances that can be used to fight against pathogenic microorganisms.

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Publication details

The article was received on 24 Aug 2017, accepted on 18 Oct 2017 and first published on 19 Oct 2017


Article type: Paper
DOI: 10.1039/C7FO01315A
Citation: Food Funct., 2017, Accepted Manuscript
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    Profiling polyphenols composition by HPLC-DAD-ESI/MSn and antibacterial activity of infusion preparations obtained from four medicinal plants

    B. E.C. Ziani, L. Barros, B. A. Zineddine, K. Bachari, S. Heleno, M. J. Alves and I. C. F. R. Ferreira, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01315A

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