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Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high fat diet fed mice

Abstract

The present study investigated the hypolipidemic properties of melanin from Lachnum YM226 (LM) in high-fat diet induced hyperlipidemic mice. After the hyperlipidemic model was established, mice were randomly divided into six groups, as follows: normal control group (NC), hyperlipidemic control group (HC), positive control group (7 mg kg−1 d−1 simvastatin) (PC), LM groups (50, 100 and 200 mg kg-1 d−1) (LM-50, LM-100, LM-200). Body weight, organ indices, lipid metabolism, antioxidant properties and liver-kidney functions of mice were examined. Moreover, the activities of lipoprotein metabolism enzymes in serum and liver tissue were also examined to study the feasible mechanism. The results imply that LM could effectively reduce body weight, total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C), atherogenic index (AI), and increase high density lipoprotein cholesterol (HDL-C). Meanwhile, treatment with LM also increased the antioxidant enzymes activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and reduced malondialdehyde (MDA) content relative to the HC group. The liver and kidney damage indices such as alanine aminotransferase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), creatinine (CRE), blood urea nitrogen (BUN) and uric acid were lowered. LM administration also significantly corrected disturbances of liver-kidney functions with no fatty deposits in the liver and a protective effect against renal histological alteration. The hypolipidemic effect was partly due to the regulation of hepatic lipase (HL) and lipoprotein lipase (LPL) in serum and liver to decrease TG markedly. This confirms the important role of LM in the prevention of hyperlipidemia.

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Publication details

The article was received on 21 Aug 2017, accepted on 30 Nov 2017 and first published on 01 Dec 2017


Article type: Paper
DOI: 10.1039/C7FO01294B
Citation: Food Funct., 2017, Accepted Manuscript
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    Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high fat diet fed mice

    F. Shi, J. Li, L. Yang, G. Hou and M. Ye, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01294B

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