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Preventive effects of taurine against D-galactose-induced cognitive dysfunction and brain damages

Abstract

The oxidative stress produced from life or environment and its resultant cellular dysfunctions are major causes of neurodegenerative disorders. The objectives of this study were to investigate if taurine (Tau) can prevent D-galactose-induced cognitive dysfunction and brain oxidative damages. Tau supplementation (100 and 400 mg/kg BW/day) spent shorter (p<0.05) searching time of D-galactose (100 mg/kg BW/day) treated mice in the reference memory experiment of water maze. Meanwhile, Tau supplementation extended (p<0.05) the searching period around target quadrant in the probe test of water maze while neuronal degeneration and nucleus shrinkage in hippocampus dentate gyrus area of D-galactose treated mice were attenuated. Tau also downregulated (p<0.05) expressions of glial fibrillary acidic protein (Gfap) and cluster of differentiation marker Cd11b; meanwhile, strengthened (p<0.05) the antioxidant capacity and lowered (p<0.05) advanced glycation end-products (AGEs) accumulation in brains. Therefore, Tau could be effective to ameliorate oxidative damage and inflammation in the brain, and apoptosis of brain cells, which further lessen the cognitive dysfunction.

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Publication details

The article was received on 05 Aug 2017, accepted on 05 Oct 2017 and first published on 05 Oct 2017


Article type: Paper
DOI: 10.1039/C7FO01210A
Citation: Food Funct., 2017, Accepted Manuscript
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    Preventive effects of taurine against D-galactose-induced cognitive dysfunction and brain damages

    Y. Chen, D. Tu, Y. Chang, C. Chou, Y. Lin, Y. Chang and C. Chiang, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01210A

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