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Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris

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Abstract

A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by analysis of physicochemical and spectral data. The backbone of CMPB90-1 is composed of (1→6)-linked α-D-glucopyranosyl and (1→3)-linked α-D-glucopyranosyl residues, with branching at O-6, which consists of (1→4)-linked β-D-mannopyranosyl and (1→6)-linked α-D-glucopyranosyl residues, respectively. β-D-Galactopyranosyl residues is the terminal unit. In vitro immunomodulatory assay revealed that CMPB90-1 promoted proliferation of splenic lymphocytes, enhanced cytotoxicity of NK cells and promoted lymphocyte secretion of the cytokine interleukin-2. Besides, CMPB90-1 upregulated T-cell subpopulation, strengthened phagocytosis function of macrophages and induced their M1 polarization. The mechanism of the effects might be due to the activation of TLR2, MAPK and NF-κB pathways. The results proposed that CMPB90-1 can be researched and developed as a new functional food.

Graphical abstract: Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris

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Publication details

The article was received on 28 Jul 2017, accepted on 03 Nov 2017 and first published on 08 Nov 2017


Article type: Paper
DOI: 10.1039/C7FO01147D
Citation: Food Funct., 2018, Advance Article
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    Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris

    S. Bi, Y. Jing, Q. Zhou, X. Hu, J. Zhu, Z. Guo, L. Song and R. Yu, Food Funct., 2018, Advance Article , DOI: 10.1039/C7FO01147D

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