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Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris

Abstract

A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by physicochemical and spectral data analysis. The backbone of CMPB90-1 is composed of (1→6)-linked α-D-glucopyranosyl and (1→3)-linked α-D-glucopyranosyl residues, with branching at O-6 which consists of (1→4)-linked β-D-mannopyranosyl and (1→6)-linked α-D-glucopyranosyl residues, respectively. β-D-galactopyranosyl residues are the terminal unit. The in vitro immunomodulatory assay revealed that CMPB90-1 promoted the proliferation of splenic lymphocytes, enhanced the cytotoxicity of NK cells and promoted lymphocyte secretion of the cytokine interleukin-2. Besides CMPB90-1 upregulated the T cell subpopulation. CMPB90-1 strengthened the phagocytosis function of macrophages and induced M1 polarization of macrophages. The mechanism of the effects might be due to the activation of TLR2, MAPKs and the NF-κB pathways. The results proposed that CMPB90-1 could be researched and developed as one of the new potential functional foods.

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Publication details

The article was received on 28 Jul 2017, accepted on 03 Nov 2017 and first published on 08 Nov 2017


Article type: Paper
DOI: 10.1039/C7FO01147D
Citation: Food Funct., 2017, Accepted Manuscript
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    Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris

    S. Bi, Y. Jing, Q. Zhou, X. Hu, J. Zhu, Z. Guo, L. Song and R. Yu, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01147D

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