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Colloidal particles for delivery of steroid glycosides


Water insoluble bioactive molecules with very high melting temperature and low solubility in water are difficult to formulate in food products. We demonstrate the synthesis of nanoscale particles form steroid glycosides using a facile liquid antisolvent precipitation method in the presence of various food grade stabilizers. Colloidal particles with sizes well below 200 nm are prepared of steroid glycosides containing extract, as well as mixtures with phytosterol. In the latter, formation of the typical for the phytosterol rod-like particles is supressed. Particle size and structure are investigated by electron microscopy and dynamic light scattering. Due to the presence of surface charge and steric stabilization, colloidal particles do not display aggregation and are stable for a period longer than one year. The results of this study are important for formulation and delivery of steroid glycoside and phytosterol bioactive molecules in the fields of food, nutraceuticals, and medical applications.

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Publication details

The article was received on 23 Jul 2017, accepted on 11 Nov 2017 and first published on 13 Nov 2017

Article type: Paper
DOI: 10.1039/C7FO01112A
Citation: Food Funct., 2017, Accepted Manuscript
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    Colloidal particles for delivery of steroid glycosides

    K. P. Velikov, M. Ruijven, A. Popp, A. R. Patel, L. Flendrig and S. Melnikov, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01112A

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