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Comparative toxic effects of butylparaben sodium, sodium diacetate and potassium sorbate to Dunaliella tertiolecta and HL7702 cells

Abstract

Butylparaben sodium (BP), sodium diacetate (SDA) and potassium sorbate (PS) are safe and internationally recognized preservatives. The aim of this study was to further evaluate their toxicity using microalgae cells, and a comparison was made with a mammalian cytotoxicity. Unicellular Dunaliella tertiolecta, was employed to test the possible toxicity of BP, SDA and PS. The results showed that three preservatives have a negative effect on D. tertiolecta, as manifested by a strong decrease in chlorophyll and carotenoids contents, viable algal cells, superoxide dismutase (SOD) and catalase (CAT) activities. SDA and PS had small effects on the normal hepatocytes HL7702, but similar to MCF-10A cells, BP is toxic to it. The effective concentration (EC50) value for HL7702 is 215.97 mg/L. It is concluded that BP, SDA and PS have low toxicity to D. tertiolecta in slightly alkaline environment, while in acid environment, SDA has moderate toxicity and PS has high toxicity. The sensitivity of algal cells is higher than that of HL7702 cells in slightly alkaline environment, which is even more under acidic conditions. D. tertiolecta can be used as a pre-screen for toxicity testing.

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Publication details

The article was received on 21 Jul 2017, accepted on 09 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7FO01102D
Citation: Food Funct., 2017, Accepted Manuscript
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    Comparative toxic effects of butylparaben sodium, sodium diacetate and potassium sorbate to Dunaliella tertiolecta and HL7702 cells

    H. Chen, X. Xu, Y. Shang and J. Jiang, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01102D

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