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Amentoflavone improves cardiovascular dysfunction and metabolic abnormalities in high fructose and fat diet-fed rats


Metabolic syndrome (MS) is a leading cause of mortality and morbidity in western countries. Amentoflavone (AMF) is a polyphenolic compound which has been found to exhibit various biological activities. In the study, we investigated the protective effects of AMF against cardiovascular and liver dysfunction in high fructose and fat diet (HFFD)-induced MS rats. AMF could evidently inhibit the changes of general metabolic parameters, including body weight, fat mass, insulin level, and glucose tolerance activity. AMF markedly protected against cardiovascular dysfunction, as evidenced by decrease of systolic blood pressure, left ventricular internal diameter in diastole (LVIDd) and left ventricular posterior wall thickness in diastole (LVPWd), increase of fractional shortening, decrease of ejection fraction, relative wall thickness, estimated LV mass, cardiac stiffness and LV wet weight in HFFD-fed rats. AMF also inhibited the increase of aortic vasoconstriction in response to phenylephrine and increased relaxation in response to acetylcholine in HFFD-fed rats. AMF reversed HFFD-induced decrease of nitrogen oxide level, increase of type 1 Ang II receptor (AT-1A) expression and decrease of AT-2A expression. AMF reduced histological and functional injury and lipid accumulation in livers in MS rats. AMF also inhibited HFFD-resulted oxidative stress, as reflected by decrease of thiobarbituric acid reactive substances content, increase of GSH level, increase of superoxide dismutase and catalase activities, and decrease of NADPH oxidase activities. In summary, we showed that AMF exhibited protective effects against cardiovascular dysfunction and liver injury in MS rats. Inhibition of renin-angiotensin system and oxidative stress contributes to the cardiovascular and liver protective activities. Our data provides novel insights into the beneficial effects of AMF against MS.

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Publication details

The article was received on 21 Jul 2017, accepted on 26 Oct 2017 and first published on 27 Oct 2017

Article type: Paper
DOI: 10.1039/C7FO01095H
Citation: Food Funct., 2017, Accepted Manuscript
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    Amentoflavone improves cardiovascular dysfunction and metabolic abnormalities in high fructose and fat diet-fed rats

    L. Qin, Y. Zhao, B. Zhang and Y. Li, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01095H

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