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Anti-obesity Molecular Mechanism of Soy Isoflavones: Weave Its Way to New Road of Therapeutics

Abstract

Obesity has ringed alarm bell globally. Advancing in food science and nutrition research is devoted to identifying food-sourced components that exert anti-obesity effects as well as investigating their molecular mechanism to modulate obesity progression. Soy foods attract more interest due to their high-protein source for human diet, and as a unique source of isoflavones. With similar chemical structures as endogenous estrogen, isoflavones are believed to interact with intracellular estrogen receptors, resulting in reduction of lipid accumulation and adipose distribution. Both in vitro and in vivo studies revealed other signaling pathways that isoflavones involved inhibiting adipogenesis and lipogenesis by interacting with various transcription factors and upstream signaling molecules. Although the biological mechanisms that cause bi-phasic effects of isoflavones and controversial results remain unknown, it is noteworthy that isoflavones exhibit pleiotropic actions in human bodies to regulate metabolism and balance, which potentially prevents and treats obesity.

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Publication details

The article was received on 21 Jul 2017, accepted on 30 Sep 2017 and first published on 02 Oct 2017


Article type: Review Article
DOI: 10.1039/C7FO01094J
Citation: Food Funct., 2017, Accepted Manuscript
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    Anti-obesity Molecular Mechanism of Soy Isoflavones: Weave Its Way to New Road of Therapeutics

    S. Wang, Y. Wang, M. Pan and C. Ho, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01094J

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