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Effect of the dietary intake of melatonin and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

Abstract

Oxylipins are lipid mediators involved in the physiopathology of all organs. Moreover, isoprostanes have been established as general and reliable in vivo oxidative stress biomarkers. Red wine has proved to exert several benefits in order to the maintenance of the oxidative organism balance. Antiradical scavenger capacity has been mainly attributed to polyphenols. However, melatonin or hydroxytyrosol should be taking into account as potent antiradical agents. The present research aimed to clarify the situation about enzymatic and oxidative injury eicosanoid urinary excretion related to the intake of three kind of red wines and their primary musts. Judging by the reduction on isoprostanes excretion, red wines consumption exhibited the highest antioxidant protection against oxidative stress attributed to its content in OHTyr (p<0.05), and in minor weigh to MEL content. Similarly, the intake of red wine leads to cardioprotective effect by reducing urinary excretion of pro-inflammatory prostaglandin 2,3-dinor-11-β-PGF2α, besides increasing vasodilator prostaglandin as PGE1, mediated by melatonin (p<0.05) and hydroxytyrosol (p<0.05) content. Concluding, red wine (specially, non-aged wine) exerts higher in vivo antioxidant capacity rather than must or alcohol.

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Publication details

The article was received on 19 Jul 2017, accepted on 04 Sep 2017 and first published on 05 Sep 2017


Article type: Paper
DOI: 10.1039/C7FO01081H
Citation: Food Funct., 2017, Accepted Manuscript
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    Effect of the dietary intake of melatonin and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

    J. Marhuenda, S. Medina, P. Martinez, S. Arina, P. Zafrilla, J. Mulero, C. Oger, J. Galano, T. Durand, A. Solana, F. Ferreres, J. J. López-García and A. Gil-Izquierdo, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01081H

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