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Issue 9, 2017
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Quality components and antidepressant-like effects of GABA green tea

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Abstract

Gamma (γ)-aminobutyric acid (GABA) green tea, with high GABA content, is a kind of special green tea. The goals of this study are to analyze the changes in quality components of green tea during anaerobic treatment, and to investigate whether or not the extract of GABA present in green tea can prevent depression or improve the depressive state of animals. Results showed that GABA content in green tea had increased significantly after anaerobic treatment. The contents of tea polysaccharides, total free amino acids, and water extracts were also increased whereas tea polyphenols were reduced. More importantly, the extract of GABA green tea could alleviate mouse depression and stress from desperate environments through the forced swim test (FST), tail suspension test (TST), mRNA and protein expression levels of GABAA receptors. Therefore, these results indicate that GABA green tea may have a health effect on prevention and alleviation of depression, and it works on the GABAergic neurotransmission of mouse cerebral cortex via up-regulating expression of the GABAA receptor α1 subunit, thus ameliorating depression.

Graphical abstract: Quality components and antidepressant-like effects of GABA green tea

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Publication details

The article was received on 14 Jul 2017, accepted on 10 Aug 2017 and first published on 14 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO01045A
Citation: Food Funct., 2017,8, 3311-3318
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    Quality components and antidepressant-like effects of GABA green tea

    J. Teng, W. Zhou, Z. Zeng, W. Zhao, Y. Huang and X. Zhang, Food Funct., 2017, 8, 3311
    DOI: 10.1039/C7FO01045A

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