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Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain

Abstract

Many studies have shown that oxidative stress is a major cause of cellular injuries in a variety of human diseases including cognitive impairment. Tea polyphenols (TP), natural plant flavonoids found in the tea plant leaves, possess the bioactivity to affect the pathogenesis of several chronic diseases via antioxidant associated mechanisms. However, the possible antioxidant and neuroprotective properties of TP in the brain of mice housed in constant darkness and H2O2-stimulated SH-SY5Y cells is yet to be elucidated. In this paper, pretreatment with TP markedly attenuated H2O2-elicited cell viability loss, mitochondrial dysfunction, suppress the induced apoptosis and dampening elevated levels of intracellular ROS and H2O2. Additionally,TP modulates nuclear translocation of Nrf2 and TrkB/CREB/BDNF signaling pathway by provoking PI3K/AKT pathway and, thus, transcriptionally regulates downstream expressions of antioxidant enzymes including HO-1, NQO-1, and BDNF in SH-SY5Y cells. Furthermore, in vivo study revealed that mice treated with constant darkness, simulating shiftwork disruption in humans, notably dampen AKT/CREB/BDNF signal pathway and the nuclear translocation of Nrf2 and its downstream phase II detoxifcation enzymes in brain tissue. Remarkably, TP supplementation through drinking water eliminated these changes. These results suggest that TP possesses protective effects against oxidative stress-triggered cognitive impairment, which might be a potential nutritional preventive strategy for neurodegenerative diseases implicated with oxidative stress in shift workers.

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Publication details

The article was received on 04 Jul 2017, accepted on 05 Oct 2017 and first published on 05 Oct 2017


Article type: Paper
DOI: 10.1039/C7FO00991G
Citation: Food Funct., 2017, Accepted Manuscript
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    Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain

    G. Qi, Y. Mi, Y. Wang, R. Li, S. Huang, X. Li and X. Liu, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00991G

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