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Dietary fucoidan of Acaudina molpadioides alter gut microbiota and mitigate intestinal mucosal injury induced by cyclophosphamide

Abstract

Cyclophosphamide (cy) is a widely used cancer drug. Many researchers have focused on prevention and alleviation of its side effects, particularly damage to the intestinal mucosal barrier. In this study, we examined the effects of fucoidan, isolated from Acaudina molpadioides, on mice with intestinal mucosa damage induced by cyclophosphamide. Our results showed that fucoidan intervention could relieve injury such as decreasing inflammation and increasing the expression of tight junction proteins, and 50-kDa fucoidan significantly increase the abundance of short chain fatty acids (SCFAs) producer-Coprococcus, Rikenella, and Butyricicoccus (p <0.05, p <0.001, and p <0.05, respectively) species within the intestinal mucosa compared with cyclophosphamide group, as determined by 16S rDNA gene high-throughput sequencing. In addition, SCFAs, particularly propionate, butyrate, and total SCFAs, were increased in feces, and SCFA receptors were upregulated in small intestine. The protective effects of fucoidan on cyclophosphamide treatment may be associated with gut microflora, and 50-kDa fucoidan had superior effects. Therefore, fucoidan may have applications as an effective supplement to protect against intestinal mucosal barrier damage during chemotherapy.

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Publication details

The article was received on 24 Jun 2017, accepted on 10 Aug 2017 and first published on 11 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00932A
Citation: Food Funct., 2017, Accepted Manuscript
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    Dietary fucoidan of Acaudina molpadioides alter gut microbiota and mitigate intestinal mucosal injury induced by cyclophosphamide

    H. Shi, Y. Chang, Y. Gao, X. Wang, X. Chen, Y. Wang, C. Xue and Q. Tang, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00932A

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