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Soluble soybean polysaccharides enhance protective effects of genistein against hepatic injury in high L-carnitine-fed mice

Abstract

This study was to develop a novel strategy for simultaneous consumption of soluble soybean polysaccharides (SSPS) to enhance absorption of genistein and its protective effects against high L-carnitine-induced hepatic injury in mice. UPLC-qTOP/MS measurement showed that SSPS observably increased urinary concentration of genistein and its metabolites in mice. The mice fed with 3% L-carnitine water for 12 weeks caused disturbance of hepatic lipid metabolism, oxidative stress and inflammation, which was observed by abnormal TC, LDL, RAHFR and MDA levels, and unusual AST, ALT, ALP, SOD and GSP-Px activities, and increased IF-1, IF-6 and TNF-α expressions. Interestingly, co-supplementation of SSPS and genistein was capable of regulating these imbalances more effectively than administration of SSPS or genistein alone, which was also confirmed by histological observations of mouse liver. These findings suggest that co-ingestion of SSPS and genistein is a feasible strategy for improving liver protection in mice.

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Publication details

The article was received on 19 Jun 2017, accepted on 21 Sep 2017 and first published on 27 Sep 2017


Article type: Paper
DOI: 10.1039/C7FO00907K
Citation: Food Funct., 2017, Accepted Manuscript
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    Soluble soybean polysaccharides enhance protective effects of genistein against hepatic injury in high L-carnitine-fed mice

    Y. Lu, W. Li and X. Yang, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00907K

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