Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions

Author affiliations


Geranium robertianum L., commonly known as Herb Robert, is an herbaceous plant popularly known for its functional properties including antioxidant and anti-inflammatory activities. In this study, the phenolic profile of leaf and stem decoctions of Geranium robertianum L. was elucidated by UHPLC-DAD-ESI-MSn analysis, and their antioxidant and anti-inflammatory potentials were assessed in vitro. Importantly, and envisaging the use of these extracts in human diets, the potential toxicity of bioactive concentrations was also addressed in macrophages and hepatocytes. Both extracts revealed high amounts of ellagitannins, although a slight prevalence of these compounds was observed in that originating from leaves. High radical scavenging activities against DPPH˙, ABTS˙+ and OH˙ were observed either for the leaf or the stem extract, as well as good activities towards ferric reducing antioxidant power, lipid peroxidation and oxygen radical absorbance capacity. In addition, both extracts were very effective at scavenging NO˙, as measured in a chemical model, while only the stem extract was able to decrease the production of this radical by stimulated macrophages. On the other hand, none of the extracts was able to modulate the activity of lipoxygenase or the expression of the inducible nitric oxide synthase. Overall, these data allowed us to conclude that G. robertianum L. stem and leaf decoctions are particularly rich in tannins. The strong scavenging effects displayed by the stem extract suggest that its anti-inflammatory activity may partially result from its anti-radical capacities towards NO˙.

Graphical abstract: Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions

Back to tab navigation

Publication details

The article was received on 14 Jun 2017, accepted on 07 Aug 2017 and first published on 08 Aug 2017

Article type: Paper
DOI: 10.1039/C7FO00881C
Citation: Food Funct., 2017,8, 3355-3365
  •   Request permissions

    Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions

    M. D. Catarino, A. M. S. Silva, M. T. Cruz and S. M. Cardoso, Food Funct., 2017, 8, 3355
    DOI: 10.1039/C7FO00881C

Search articles by author