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Issue 10, 2017
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Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer

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Abstract

Mango leaf tea has been traditionally used by different cultures to reduce inflammation in the body. There is evidence that chronic inflammation increases the risk of cancer. This study investigates the antitumoural effects of pressurized mango leaf extracts on minimally (MCF7) and highly invasive (MDA-MB-231) breast cancer cells as well as on non-tumourigenic cells (MCF10). Extracts showed protective properties against oxidation and cytotoxic effects against breast cancer cell lines, causing minor damage to non-carcinogenic cells. Nonetheless, some selective activity, depending on hormone receptor status, was observed. This was possibly related to the presence of minor compounds. Extracts with high levels of gallotannins showed cytotoxic action against MCF7 cells, while those which had methyl gallate and homomangiferin as common components were more effective against MDA-MB-231 cells. Therefore, the cytotoxic effect of mango leaf extracts might be attributed to the synergistic effect of different polyphenols and not just to mangiferin on its own as the predominant compound in mango leaves.

Graphical abstract: Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer

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Publication details

The article was received on 14 Jun 2017, accepted on 22 Aug 2017 and first published on 22 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00877E
Citation: Food Funct., 2017,8, 3610-3620
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    Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer

    M. T. Fernández-Ponce, A. López-Biedma, C. Sánchez-Quesada, L. Casas, C. Mantell, J. J. Gaforio and E. J. Martínez de la Ossa, Food Funct., 2017, 8, 3610
    DOI: 10.1039/C7FO00877E

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