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20(s)-Protopanaxadiol (PPD) increases the radiotherapy sensitivity of laryngeal carcinoma

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Abstract

Laryngeal carcinoma (LC) is one of the most prevalent malignant tumors in the head and neck area. Due to its high morbidity and mortality, LC poses a serious threat to human life and health. Even with surgical removal, some patients were not sensitive to radiotherapy or experienced transfer or recurrence. 20(s)-Protopanaxadiol (PPD), a natural product from Panax ginseng, has been reported to have cytotoxic effects against several cancer cell lines. However, whether it can improve the radiation sensitivity and the underlying mechanism of PPD's sensitization effect is still unknown. Herein, from in vitro and in vivo experiments, we found that the combination of PPD and radiation not only significantly inhibited proliferation and induced apoptosis, but also suppressed the tumor growth in mouse models. These findings confirmed the role of PPD in enhancing the sensitivity of radiotherapy. Moreover, our work showed that the expression levels of mTOR and its downstream effectors decreased remarkably after PPD addition when compared to radiation only. This result suggested that PPD's excellent synergistic effects with radiation might be associated with the down-regulation of the mTOR signaling pathway in Hep-2 cells.

Graphical abstract: 20(s)-Protopanaxadiol (PPD) increases the radiotherapy sensitivity of laryngeal carcinoma

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Publication details

The article was received on 11 Jun 2017, accepted on 05 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7FO00853H
Citation: Food Funct., 2017, Advance Article
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    20(s)-Protopanaxadiol (PPD) increases the radiotherapy sensitivity of laryngeal carcinoma

    B. Teng, L. Zhao, J. Gao, P. He, H. Li, J. Chen, Q. Feng and C. Yi, Food Funct., 2017, Advance Article , DOI: 10.1039/C7FO00853H

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