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Effect of dietary magnesium and caseinphosphopeptides on bone metabolism in rats

Abstract

The effects of dietary magnesium (Mg) or caseinphosphopeptides (CPPs) on bone metabolism have been reported. However, few studied have investigated the effects the Mg and CPPs were supplemented simultaneously. Sixty-three 3-week-old Sprague-Dawley male rats were divided into seven groups and fed on a specified diet for 45 days. Body characteristics, bone physicochemical indicators, and bone metabolism indicators relative to bone metabolism were analyzed. We found that, first, a dietary Mg deficiency resulted in increased bone formation and decreased bone resorption. Second, dietary Mg or CPPs supplementation promoted bone formation and prevented bone resorption. Third, dietary Mg supplementation with CPPs also functioned to enhance bone formation and prevent bone resorption. There were synergistic effects in femur length, serum parathyroid hormone, urinary deoxypyridinoline of HS-Mg-CPPs group (0.2% Mg, 0.1% CPPs). The increase in femur length of HS-Mg-CPPs group compared with control group was 6% which was much higher than that of HS-Mg (1%) or CPPs (5%). The induction in serum parathyroid hormone content in HS-Mg-CPPs group was 33% compared with control group which was higher than that of induction of HS-Mg (19%) or CPPs (23%) group. The induction in deoxypyridinoline content of HS-Mg-CPPs (43%) group compared with control group were remarkablely higher than that of HS-Mg (8%) or CPPs (16%). Overall our results demonstrated that high dose of Mg (0.2%) and CPPs (0.1%) in combination produced synergistic effects in in femur length, serum parathyroid hormone, urinary deoxypyridinoline in rats, which is important for better understanding of the effect Mg and CPPs on bone metabolism.

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Publication details

The article was received on 09 Jun 2017, accepted on 20 Sep 2017 and first published on 28 Sep 2017


Article type: Paper
DOI: 10.1039/C7FO00842B
Citation: Food Funct., 2017, Accepted Manuscript
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    Effect of dietary magnesium and caseinphosphopeptides on bone metabolism in rats

    G. Liu, J. Miao, S. Sun, Z. Luo, Z. Xia, B. Guo, F. Liu, Y. Chen, D. Ying and Y. Cao, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00842B

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