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Mice gut microbiota programming by infant food profile. The effect on growth, gut microbiota and immune system.

Abstract

During the complementary feeding (CF) period nutritional imbalances can have negative consequences not only on a child's health in the short term but also later in adulthood, as a phenomenon known as "nutritional programming" takes place. The aim of this study was to evaluate possible changes in body growth, gut microbiota (GM) and immune system in mice fed with two different commercial sterilized baby foods in jars (BFJs) for CF. Mice fed the different BFJs (A and B group) showed an accelerated growth from the fifth week of life when compared with the control (C) group. Group A showed the higher BMI, post-weaning growth rate, IL-10 levels and a decrease in Lactobacillus group. Group B showed significant decrease in total bacterial counts, Lactobacillus group, Enteroccus spp. and Bacteroidetes-Prevotella. Bifidobacterium genus tended to be lower in groups A and B. Akkermansia muciniphila was more frequently detected in goup C. The results showed by groups A and B can be attributed to the BFJs fatty acid profile, rich in UFAs. This study demonstrates for the first time that commercial BFJs composition during CF might be a “programming” factor on body growth, GM and immune system.

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Publication details

The article was received on 05 Jun 2017, accepted on 04 Sep 2017 and first published on 05 Sep 2017


Article type: Paper
DOI: 10.1039/C7FO00819H
Citation: Food Funct., 2017, Accepted Manuscript
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    Mice gut microbiota programming by infant food profile. The effect on growth, gut microbiota and immune system.

    E. P. Sánchez-Samper, C. Gómez-Gallego, P. Andreo-Martínez, S. Salminen and G. Ros, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00819H

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