Jump to main content
Jump to site search


Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress

Author affiliations

Abstract

Epidemiological studies strongly support the role of procyanidin-rich beverages and fruit in the prevention of cardiovascular diseases. Procyanidins extracted from the litchi pericarp (LPPC), a new source of procyanidins, were isolated and identified in our laboratory and have been proven to possess strong antioxidant activity in vitro. In the present study, we investigated the anti-atherosclerotic effects of LPPC in apolipoprotein E knockout (ApoE KO) mice fed a high fat diet for 24 weeks. LPPC (100 mg kg−1 body mass daily) significantly reduced the atherosclerotic lesion size (P < 0.01 versus ApoE KO mice), excess NO production and iNOS expression. Moreover, the mRNA and protein expressions of eNOS in the aortas of ApoE KO mice were increased by LPPC which further explains the endothelial protective action of LPPC. LPPC also showed profound antioxidant effects in ApoE KO mice. Plasma TBARS contents and the mRNA expression for NADPH oxidase (p47phox, p67phox, NOX-2/gp91phox and NOX-4) in the aortas of ApoE KO mice were significantly reduced, whereas plasma SOD activity was markedly elevated by LPPC. These results elucidated that LPPC could ameliorate atherosclerosis in ApoE-KO mice by improving NO bioavailability and reducing oxidative stress through NADPH oxidase-dependent mechanisms.

Graphical abstract: Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress

Back to tab navigation

Publication details

The article was received on 20 May 2017, accepted on 26 Sep 2017 and first published on 26 Sep 2017


Article type: Paper
DOI: 10.1039/C7FO00747G
Citation: Food Funct., 2017, Advance Article
  •   Request permissions

    Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress

    S. Rong, X. Hu, S. Zhao, Y. Zhao, X. Xiao, W. Bao and L. Liu, Food Funct., 2017, Advance Article , DOI: 10.1039/C7FO00747G

Search articles by author

Spotlight

Advertisements