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Issue 10, 2017
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Role of phytochemicals in the modulation of miRNA expression in cancer

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Abstract

MicroRNAs (miRNAs) are single-stranded non-coding endogenous RNAs linked with normal developmental and physiological processes. Recent studies have demonstrated that the dysregulation of miRNAs plays an important role in the beginning, progression, and metastasis of many cancers. Additionally, they are involved in the regulation of the epithelial-to-mesenchymal transition (EMT) in many cancer cells. Several studies have suggested that phytochemicals play an important role in the modulation of miRNA expression, which is related to changes in oncogenes, tumour suppressors, and cancer-related protein expression. Hence, phytonutrients can suppress tumour development, prevent metastasis, reverse the EMT, and improve drug sensitivity via the modulation of miRNA expression. In this review, we discuss tumour-suppressing and oncogenic miRNAs and the mechanism of action for miRNAs as well as the role of phytochemicals in the modulation of miRNAs in various cancer cells.

Graphical abstract: Role of phytochemicals in the modulation of miRNA expression in cancer

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Publication details

The article was received on 18 May 2017, accepted on 20 Jul 2017 and first published on 07 Aug 2017


Article type: Review Article
DOI: 10.1039/C7FO00739F
Citation: Food Funct., 2017,8, 3432-3442
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    Role of phytochemicals in the modulation of miRNA expression in cancer

    T. Debnath, N. C. Deb Nath, E. Kim and K. Lee, Food Funct., 2017, 8, 3432
    DOI: 10.1039/C7FO00739F

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