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Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice

Abstract

Theasinensins have been identified as the major group of unique catechin dimers mainly found in oolong tea and black tea. Previous studies have reported TSA exhibits antioxidative, anti-inflammatory and anti-cancer activities in vitro and in vivo. However, little is known about the hepatoprotective effect of TSA. Thus, the aim of this study was to investigate the inhibitory effect of TSA on carbon tetrachloride (CCl4)-induced liver injury in mice. After intraperitoneal injection of CCl4 for eight weeks, histological lesions in the liver tissue and elevated alanine aminotransferase and alkaline phosphatase serum levels were found in mice. Conversely, oral administration of TSA relieved CCl4-induced liver injury as well as ameliorated liver functions. Moreover, our immunohistochemical staining results revealed that collagen deposition was profoundly reduced due to supplementation of TSA. Finally, we also found that hepatic α-smooth muscle actin (α-SMA) and matrix metallopeptidase 9 (MMP-9) expression was also suppressed through inhibition of transforming growth factor β (TGF-β). Taken together, our current findings suggest that TSA may serve as a potent bioactive constituent from oolong tea that acts against liver fibrosis through inhibition of HSC activation.

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Publication details

The article was received on 12 May 2017, accepted on 27 Jul 2017 and first published on 31 Jul 2017


Article type: Paper
DOI: 10.1039/C7FO00700K
Citation: Food Funct., 2017, Accepted Manuscript
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    Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice

    W. Hung, G. Yang, Y. Wang, Y. Chiou, Y. Tung, M. Yang, B. Wag, C. Ho, Y. Wang and M. Pan, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00700K

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