Jump to main content
Jump to site search


Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism

Author affiliations

Abstract

Probiotics, as dietary supplements, transmit their major effects through the regulation of gut microbiota. According to a previous study, one possible mechanism of Lactobacillus casei CCFM419 protection against diabetes may involve gut flora. To test this hypothesis, high fat and streptozotocin-induced C57BL/6J mice were fed L. casei CCFM419 at 108, 109, and 1010 colony forming units (CFU). Compared to untreated mice, 109 CFU of L. casei CCFM419 attenuated several symptoms of diabetes, including fasting blood glucose, postprandial blood glucose, glucose intolerance, and insulin resistance. In addition, this CFU level also decreased the levels of the inflammatory markers tumor necrosis factor-α and interleukin-6 and increased intestinal glucagon-like peptide-1 (GLP-1) levels, which are associated with the production of short chain fatty acids (SCFAs). The 16S rRNA gene sequencing of fecal samples demonstrated that 109 CFU of L. casei CCFM419 dramatically increased the abundance of Bacteroidetes and decreased the proportion of Firmicutes at the phylum level, and enriched Bifidobacterium, Lactobacillus, and SCFA-producing bacteria, including Allobaculum and Bacteroides. These findings suggested that L. casei CCFM419 modified the gut flora-SCFA-inflammation/GLP-1 mechanism to ameliorate type 2 diabetes.

Graphical abstract: Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism

Back to tab navigation

Publication details

The article was received on 19 Apr 2017, accepted on 16 Jul 2017 and first published on 17 Jul 2017


Article type: Paper
DOI: 10.1039/C7FO00593H
Citation: Food Funct., 2017, Advance Article
  •   Request permissions

    Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism

    G. Wang, X. Li, J. Zhao, H. Zhang and W. Chen, Food Funct., 2017, Advance Article , DOI: 10.1039/C7FO00593H

Search articles by author

Spotlight

Advertisements