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Issue 10, 2017
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Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo

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Abstract

The aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in vivo. PAP has been suggested to have anti-oxidation, anti-apoptosis, immunoregulation, antimicrobial, antitussive, and expectorant abilities. In this study, PAP was extracted and the major components of PAP were analyzed. It was shown that PAP pretreatment remarkably improved redox homeostasis, both in human embryonic kidney 293 (HEK293) cells and in BALB/c mice. Administration of PAP attenuated the mitochondrial dysfunction, degeneration, and fibrosis of kidney induced by Cd. Furthermore, PAP exhibited anti-apoptotic activity, which involved regulating both the mitochondria-mediated intrinsic apoptotic pathway and the death receptor-initiated extrinsic pathway. These results suggest that PAP is a potential therapeutic agent for Cd-induced nephrotoxicity.

Graphical abstract: Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo

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Publication details

The article was received on 31 Mar 2017, accepted on 10 Aug 2017 and first published on 15 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00495H
Citation: Food Funct., 2017,8, 3636-3646
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    Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo

    R. Shen, D. Liu, C. Hou, D. Liu, L. Zhao, J. Cheng, D. Wang and D. Bai, Food Funct., 2017, 8, 3636
    DOI: 10.1039/C7FO00495H

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