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Antiobesity effects of zeaxanthin on 3T3-L1 preadipocyte and high fat induced obese mice

Abstract

Zeaxanthin as carotenoids has been proved to exhibit anti-lipogenesis effect; however, its further mechanism is less known. We evaluated the effects of zeaxanthin on inhibition of adipogenesis in 3T3-L1 adipocytes and anti-obesity in high-fat diet fed C57BL/6J mice. Zeaxanthin significantly decreased intracellular lipid content in a dose-dependent manner (5-15 μM) in adipocytes without causing cytotoxicity. In high-fat-diet-induced obese mice, oral administration of 20mg/kg zeaxanthin attenuated the progression of obesity and improved dyslipidaemia. It plays anti-adipogenic effect through down-regulated the transcriptional factors and adipocyte-specific genes involved in adipogenesis both in vitro and in vivo. Furthermore, zeaxanthin treatment reversed the MDI (0.5 mM 3-isobutyl-1-methylxanthine, 1.0 µM dexamethasone and 1.0 µg/mL insulin) and HFD (high-fat diet) -induced inhibition of AMPK phosphorylation in adipocytes and epididymal adipose tissues, respectively, thereby modulating energy metabolism. These results indicated that zeaxanthin plays an anti-adipogenic and anti-obesity roles by inducing AMPK activation, inhibiting lipogenesis and decreasing intracellular lipid content, adipocytes size, and adipose weight.

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Publication details

The article was received on 29 Mar 2017, accepted on 04 Jul 2017 and first published on 24 Jul 2017


Article type: Paper
DOI: 10.1039/C7FO00486A
Citation: Food Funct., 2017, Accepted Manuscript
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    Antiobesity effects of zeaxanthin on 3T3-L1 preadipocyte and high fat induced obese mice

    M. Liu, H. Liu, J. Xie, Q. Xu, C. Pan, J. Wang, X. Wu, S. yaqoob, M. Zheng and J. Liu, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00486A

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