Jump to main content
Jump to site search


Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice

Author affiliations

Abstract

Epidemiological evidence indicates that anthocyanin consumption reduces the incidence of chronic and degenerative diseases. Therefore, the present study aimed to determine whether black rice anthocyanin (BRA), black soybean anthocyanin (BSA), and purple corn anthocyanin (PCA) could mitigate oxidative stress and inflammation associated obesity in C57BL/6 mice fed with a high-fat diet. BRA, BSA, or PCA was administered at doses of 200 mg kg−1 throughout the 12-week experiment and reduced the bodyweight by 9.6%, 13.3%, or 16.6%, respectively. Furthermore, BRA, BSA or PCA administration could effectively increase fecal butyric acid levels, elevate hepatic SOD and GPx activities, decrease lipid peroxidation, and downregulate the gene expression levels of TNFα, IL-6, iNOS, and NF-κB. Hence, BRA, BSA, or PCA might ameliorate diet-induced obesity by alleviating both oxidative stress and inflammation.

Graphical abstract: Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Mar 2017, accepted on 21 Jul 2017 and first published on 24 Jul 2017


Article type: Paper
DOI: 10.1039/C7FO00449D
Citation: Food Funct., 2017, Advance Article
  •   Request permissions

    Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice

    T. Wu, X. Guo, M. Zhang, L. Yang, R. Liu and J. Yin, Food Funct., 2017, Advance Article , DOI: 10.1039/C7FO00449D

Search articles by author

Spotlight

Advertisements