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Issue 9, 2017
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Characterization of active compounds from Gracilaria lemaneiformis inhibiting the protein tyrosine phosphatase 1B activity

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Abstract

Gracilaria lemaneiformis, an edible alga, with various bioactivities is a traditional dish and a favorite food. In the present study, its n-hexane extract showed strong protein tyrosine phosphatase 1B inhibitory activity after screening. To understand the activity composition, nineteen compounds were identified from this extract by GC-MS. The protein tyrosine phosphatase 1B inhibitory activity of the identified compounds was further screened by means of molecular docking individually. As a result, 2,2′-methylenebis-6-(1,1-dimethylethyl)-4-methyl-phenol with the lowest binding energy of −6.70 kcal mol−1 was discovered from the complex extract, and its inhibitory activity against protein tyrosine phosphatase 1B was proved in vitro. The IC50 value was 53.27 ± 0.54 μM. Therefore, this compound and its source Gracilaria lemaneiformis were suggested to be utilized as a functional food with potential protein tyrosine phosphatase 1B inhibitory activity.

Graphical abstract: Characterization of active compounds from Gracilaria lemaneiformis inhibiting the protein tyrosine phosphatase 1B activity

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Publication details

The article was received on 08 Mar 2017, accepted on 07 Aug 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00376E
Citation: Food Funct., 2017,8, 3271-3275
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    Characterization of active compounds from Gracilaria lemaneiformis inhibiting the protein tyrosine phosphatase 1B activity

    X. Guo, D. Gu, M. Wang, Y. Huang, H. Li, Y. Dong, J. Tian, Y. Wang and Y. Yang, Food Funct., 2017, 8, 3271
    DOI: 10.1039/C7FO00376E

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