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Characterization of active compounds from Gracilaria lemaneiformis inhibiting protein tyrosine phosphatase 1B activity

Abstract

Gracilaria lemaneiformis, an edible alga, with the various bioactivities is a traditional dish and a favorite food. In the present study, its n-hexane extract showed the strong protein tyrosine phosphatase 1B inhibitory activity after screening. To understand the activity composition, nineteen compounds were identified from this extract by GC-MS. The protein tyrosine phosphatase 1B inhibitory activity of identified compounds was further screened by means of molecular docking individually. As a result, phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl- with the lowest binding energy of -6.70 kcal/mol was discovered from the complex extract, and its inhibitory activity against protein tyrosine phosphatase 1B was proofed in vitro. The IC50 value was 53.27±0.54 μM. Therefore, this compound and its source Gracilaria lemaneiformis were suggested to be utilized as a functional food with potential protein tyrosine phosphatase 1B inhibitory activity.

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Publication details

The article was received on 08 Mar 2017, accepted on 07 Aug 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00376E
Citation: Food Funct., 2017, Accepted Manuscript
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    Characterization of active compounds from Gracilaria lemaneiformis inhibiting protein tyrosine phosphatase 1B activity

    X. Guo, D. Gu, M. Wang, Y. Huang, H. Li, Y. Dong, J. Tian, Y. Wang and Y. Yang, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00376E

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