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Anti-inflammatory effects of ethanol extract of Aster glehni via inhibition of NF-κB activation in mice with DSS-induced colitis

Abstract

Although Aster glehni has been reported to prevent diabetes mellitus, hypercholesterolemia, insomnia, and cardiovascular disease, the anti-inflammatory effect of Aster glehni in colonic tissue remains unclear. In this study, we investigated the anti- inflammatory effects and the underlying molecular mechanism of ethanol extract of Aster glehni (AG) in mice with dextran sulfate sodium (DSS)-induced colitis. AG significantly attenuated DSS-induced DAI scores, which implied that it suppressed diarrhea, gross bleeding, and the infiltrations of immune cells. AG administration also effectively prevented shortening of colon length and enlargement of spleen size. Histological examinations indicated that AG suppressed colonic damage and thickness on muscle layer induced by DSS. In addition, AG inhibited the production of pro-inflammatory cytokines, such as, TNF-α, IL-1β, and IL-6, and the protein expression of COX-2 and iNOS in mice with DSS-induced colitis. Administration with AG suppressed the activation of nuclear factor-κB (NF-κB) including the nuclear translocation of p65 NF-κB subunit, phosphorylation and degradation of IκB-α. Taken together, these findings suggest that the anti-inflammatory effects of AG are mainly related to the inhibition of the expressions of inflammatory mediators via NF-κB inactivation, and support its possible therapeutic application in colitis.

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Publication details

The article was received on 07 Mar 2017, accepted on 14 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7FO00369B
Citation: Food Funct., 2017, Accepted Manuscript
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    Anti-inflammatory effects of ethanol extract of Aster glehni via inhibition of NF-κB activation in mice with DSS-induced colitis

    J. Choi, K. Chung, B. Jin, S. Cheon, A. Nugroho, S. Roh and H. An, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00369B

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