Jump to main content
Jump to site search

Issue 5, 2017
Previous Article Next Article

In vivo fermentation of a Pleurotus eryngii polysaccharide and its effects on fecal microbiota composition and immune response

Author affiliations

Abstract

A novel, homogeneous Pleurotus eryngii polysaccharide (PEP) (molecular weight 426 kDa, purity 91.25 ± 3.14%) which mainly consisted of glucose with β-type glycosidic linkages was used to investigate in vivo fermentation behavior and effects on immune response in mice. Different doses (0.2, 0.4, 0.8 g per kg body weight) were orally administered to the mice for a period of six weeks. The results showed that the SCFA concentration, pH value, and moisture contents of cecum and colon contents were significantly altered with high-dose PEP treatment compared to the control group (P < 0.05). Moreover, the fecal microbiota in the PEP treated group was found to be structurally different compared to the control group; especially, the Porphyromonadaceae, Rikenellaceae, Bacteroidaceae and Lactobacillaceae abundances were all increased at the family level. In addition, the exerted immune response was significantly altered after the high-dose PEP oral administration. This exploratory study indicated that intake of PEP could have a positive role in gastrointestinal tract health.

Graphical abstract: In vivo fermentation of a Pleurotus eryngii polysaccharide and its effects on fecal microbiota composition and immune response

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Mar 2017, accepted on 26 Apr 2017 and first published on 28 Apr 2017


Article type: Paper
DOI: 10.1039/C7FO00341B
Citation: Food Funct., 2017,8, 1810-1821
  •   Request permissions

    In vivo fermentation of a Pleurotus eryngii polysaccharide and its effects on fecal microbiota composition and immune response

    G. Ma, B. M. Kimatu, L. Zhao, W. Yang, F. Pei and Q. Hu, Food Funct., 2017, 8, 1810
    DOI: 10.1039/C7FO00341B

Search articles by author

Spotlight

Advertisements