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Concentration of estrogen and progesterone in breast milk and their relationship with mother’s diet

Abstract

The aim of the present study was to determine the concentrations of estradiol (E2), estriol (E3) and progesterone in breast milk over different lactation periods, and to assess their relationship with mother’s diet. Ninety-six breast milk samples as well as 24-hour dietary records from 32 lactating mothers were collected on day 1 (colostrum), day 14 (transitional milk) and day 42 (mature milk) after delivery in Hangzhou, China. Concentrations of E2, E3 and progesterone differed significantly through different period of lactation (P < 0.001). The content of E2 in colostrum, transitional milk and mature milk was 1.60 ± 0.96 g/L, 0.83 ± 0.36 g/L and 1.26 ± 0.48 g/L, respectively. The concentrations of E3 was 2.09 ± 1.66 g/L, 2.23 ± 1.74 g/L and 4.64 ± 2.15 g/L, respectively. The concentrations of progesterone was 6.10 ± 8.30 g/L, 4.25 ± 4.76 g/L and 1.70 ± 2.42 g/L, respectively. Concentration of progesterone in breast milk was significantly negatively correlated with intake of protein (p = 0.015), fat (p = 0.008), vegetables (p = 0.012), meat and eggs (p = 0.036). While concentration of E3 was significantly positive correlated with intake of soy products (p = 0.025). These information indicate that concentration of E2, E3 and progesterone in breast milk varied over lactating period. Dietary intake will to some extent affect the contents of E3 and progesterone in breast milk.

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Publication details

The article was received on 26 Feb 2017, accepted on 30 Jul 2017 and first published on 04 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00324B
Citation: Food Funct., 2017, Accepted Manuscript
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    Concentration of estrogen and progesterone in breast milk and their relationship with mother’s diet

    M. Lu, H. Xiao, K. Li, J. Jiang, K. Wu and D. Li, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00324B

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