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Cyanidin-3-O-β-glucoside combined with its metabolite protocatechuic acid attenuated the activation of mice hepatic stellate cells

Abstract

Previous studies indicated that Cyanidin-3-O-β-glucoside (C3G) as a classical anthocyanin exerted an anti-fibrotic effect in the liver, but the bioavailability was quite low. This study was to explore the restraining effect of C3G and its metabolite protocatechuic acid (PCA) on the activation of hepatic stellate cells (HSCs). Our data demonstrated that the treatment of C3G on carbon tetrachloride-treated mice model inhibited liver fibrosis and HSCs activation. In vitro, both of C3G and PCA reserved the lipid droplets and retinol in primary HSCs, and additionally inhibited mRNA expression of α-smooth muscle actin and collagen I, but elevated the level of matrix metalloproteinase-2 and liver X receptors. Only PCA suppressed the levels of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) secreted from HSCs significantly. In addition, C3G and PCA inhibited the proliferation and migration of HSCs. In conclusion, PCA mainly explained the in vivo inhibiting effect of C3G on HSCs activation and liver fibrosis.

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Publication details

The article was received on 16 Feb 2017, accepted on 27 May 2017 and first published on 29 May 2017


Article type: Paper
DOI: 10.1039/C7FO00265C
Citation: Food Funct., 2017, Accepted Manuscript
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    Cyanidin-3-O-β-glucoside combined with its metabolite protocatechuic acid attenuated the activation of mice hepatic stellate cells

    X. Jiang, T. Shen, X. Tang, W. Yang, H. Guo and W. Ling, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00265C

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