Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

Author affiliations

Abstract

Brassica phytochemicals exert a broad spectrum of health-promoting activities. The aim of this study was to investigate the possible beneficial effects of a cauliflower leaf powder (CLP)-enriched diet to prevent inflammation and oxidative stress resulting from injection of lipopolysaccharide (LPS) into rabbits. Animals (24 rabbits) were randomly divided into two groups and fed with a standard diet (SD) or a standard diet supplemented with a 100 g kg−1 diet of CLP. After 60 days, six rabbits of both groups received a LPS injection (100 μg per kg body weight). Serum samples collected after 90 min of LPS injection were assessed for their content of both inflammatory biomarkers such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and matrix-metalloproteinases (MMP-2 and MMP-9) and oxidative stress biomarkers such as thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). LPS increased the levels of TNF-α, IL-6, and TBARS as well as MMP-2 and MMP-9 activities, whereas it decreased the GSH levels and SOD and CAT activities. In conclusion, preventive supplementation with CLP can protect rabbits from the inflammation and oxidative stress induced by LPS.

Graphical abstract: Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

Back to tab navigation

Publication details

The article was received on 15 Feb 2017, accepted on 27 Jun 2017 and first published on 01 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00253J
Citation: Food Funct., 2017,8, 3288-3296
  •   Request permissions

    Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

    M. Larocca, A. M. Perna, A. Simonetti, E. Gambacorta, A. Iannuzzi, A. Perucatti and R. Rossano, Food Funct., 2017, 8, 3288
    DOI: 10.1039/C7FO00253J

Search articles by author

Spotlight

Advertisements