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Antioxidant and anti-inflammatory effects of leaves cauliflower powder-enriched diet against LPS induced toxicity in rabbits

Abstract

ABSTRACT Brassica phytochemicals exert a broad spectrum of health-promoting activities. The aim of this study was to investigate the possible beneficial effects of cauliflower leaves powder (CLP)-enriched diet to prevent inflammation and oxidative stress resulting from injection of lipopolysaccharide (LPS) into rabbits. Animals (24 rabbits), were randomly divided in two groups and fed with standard diet (SD) or standard diet supplemented with 100 g/kg diet of CLP. After 60 days, six rabbits of both groups received a LPS injection (100 µg/kg body weight). Sera samples, collected after 90 min of LPS injection, were assessed for their content of both inflammatory biomarkers, as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and matrix-metalloproteinases (MMP-2 and MMP-9) and oxidative stress biomarkers, as thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). LPS increased the level of TNF-α, IL-6, and TBARS as well as MMP-2, MMP-9 activities, whereas decreased the GSH levels and SOD, CAT activities. In conclusion, preventive supplementation with CLP can protect rabbits from inflammation and oxidative stress induced by LPS.

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Publication details

The article was received on 15 Feb 2017, accepted on 27 Jun 2017 and first published on 01 Aug 2017


Article type: Paper
DOI: 10.1039/C7FO00253J
Citation: Food Funct., 2017, Accepted Manuscript
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    Antioxidant and anti-inflammatory effects of leaves cauliflower powder-enriched diet against LPS induced toxicity in rabbits

    M. Larocca, A. M. Perna, A. Simonetti, E. Gambacorta, A. Iannuzzi, A. Perucatti and R. Rossano, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00253J

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