Jump to main content
Jump to site search

Issue 5, 2017
Previous Article Next Article

Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae

Author affiliations

Abstract

Pleurotus ferulae is an edible mushroom and has been used in Uygur medicine for a long time. In this study, we purified polysaccharides from P. ferulae (PFPS) and investigated its structural characteristics. We obtained a homogeneous PFPS with a molecular weight of around 1600 kDa and prominent characteristic polysaccharide groups, which mainly contained glucose (97%), followed by mannose and galactose (3%). Both 1H and 13C NMR spectra indicated that PFPS contained both α- and β-anomeric configurations. Atomic force microscopy and Congo red-staining data further suggested that PFPS belonged to a linear branched structure that existed in flexible single chains at low concentrations and could form aggregates such as a triple-helical structure at high concentrations. Moreover, PFPS promoted the maturation of dendritic cells through a TLR4 mediated signaling pathway, which is characterized by the increased expressions of CD40, CD86, IL-12 and TNF-α and the decreased endocytosis. The results suggest that PFPS has immunoregulatory activities.

Graphical abstract: Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Feb 2017, accepted on 10 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7FO00227K
Citation: Food Funct., 2017,8, 1905-1914
  •   Request permissions

    Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae

    J. Li, P. Yuan, X. Wang, A. Aipire, M. Li, J. Yang, H. Tao, T. Ying, C. Fu, X. Wei, F. Zhang and J. Li, Food Funct., 2017, 8, 1905
    DOI: 10.1039/C7FO00227K

Search articles by author

Spotlight

Advertisements