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The effects of Lycium barbarum L. (L. barbarum) on cardiometabolic risk factors: a meta-analysis of randomized controlled trials

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Abstract

The effects of Lycium barbarum L. (L. barbarum) on the cardiometabolic risk factors from randomized controlled trials (RCTs) have shown inconsistent results. The present meta-analysis aimed to investigate the effects of L. barbarum supplementation on the cardiometabolic risk factors. A systematic literature search was performed in Chinese National Knowledge Infrastructure (CNKI), PubMed, Scopus, and Wanfang databases updated to March 2017. The mean changes in cardiometabolic risk factors were calculated as the weighted mean difference (WMD) using a random-effects model. Seven RCTs with a total of 548 subjects were included. The pooled estimate showed that L. barbarum intervention significantly reduced the fasting glucose concentrations (−0.36 mmol L−1/−6.5 mg dL−1; 95% confident interval (CI): −0.62, −0.10 mmol L−1/−11.3, −1.8 mg dL−1). In addition, L. barbarum supplementation marginally reduced the concentrations of total cholesterol (TC) (−0.30 mmol L−1/−11.6 mg dL−1; 95% CI: −0.75, 0.15 mmol L−1/−29.0, 5.8 mg dL−1; P = 0.189) and triglyceride (TG) (−0.20 mmol L−1/−17.7 mg dL−1; 95% CI: −0.46, 0.05 mmol L−1/−40.7, 4.4 mg dL−1; P = 0.122), but the summary estimates did not reach statistical significance. No benefit was found in relation to bodyweight and blood pressure. The present meta-analysis provides some evidence that supplemental L. barbarum might have favourable effect on glucose control.

Graphical abstract: The effects of Lycium barbarum L. (L. barbarum) on cardiometabolic risk factors: a meta-analysis of randomized controlled trials

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Publication details

The article was received on 06 Feb 2017, accepted on 29 Mar 2017 and first published on 29 Mar 2017


Article type: Review Article
DOI: 10.1039/C7FO00183E
Citation: Food Funct., 2017, Advance Article
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    The effects of Lycium barbarum L. (L. barbarum) on cardiometabolic risk factors: a meta-analysis of randomized controlled trials

    X. Guo, Z. Li, H. Cai and D. Li, Food Funct., 2017, Advance Article , DOI: 10.1039/C7FO00183E

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