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Issue 6, 2017
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Fiber purified extracts of carob fruit decrease carbohydrate absorption

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The postprandial state plays a central role in the development and setting of chronic diseases. Condensed tannins (CT) are polyphenols with a known ability to modify carbohydrate digestion and absorption. The high concentration of CT in the pulp of carob fruit suggests a potential antidiabetic effect. The aim of this work was to analyze the in vitro and in vivo effects of carob fruit extract (CFE) on the digestion and absorption of carbohydrates. α-Glucosidase activity and glucose diffusion were tested in vitro using 0.5, 1, 2 and 5 mg mL−1 CFE concentrations. Two in vivo absorption studies, acute and subchronic, were carried out in four groups of 6 two-month-old male Wistar rats (control and CFE 25, 50 and 150 mg per kg b.w.), administering 1 mL of olive oil and 0.5 g per kg b.w. of glucose solution by oral gavage. CFE significantly inhibited α-glucosidase activity, through a competitive mechanism, from 1 mg mL−1, and also reduced glucose diffusion in a dose-dependent manner. In the acute study, CFE (50 and 150 mg per kg b.w.) significantly reduced the area under the curve (AUC) of blood glucose. Subchronic CFE administration induced further AUC decreases; and CFE at 150 mg per kg b.w. reduced sodium–glucose-linked transporter-1 (SGLT1) levels in the duodenum. This study demonstrates the hypoglycemic properties of CFE, highlighting its potential role as a suitable nutritional strategy in diabetic patients.

Graphical abstract: Fiber purified extracts of carob fruit decrease carbohydrate absorption

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Publication details

The article was received on 31 Jan 2017, accepted on 28 Apr 2017 and first published on 02 May 2017

Article type: Paper
DOI: 10.1039/C7FO00166E
Citation: Food Funct., 2017,8, 2258-2265
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    Fiber purified extracts of carob fruit decrease carbohydrate absorption

    A. Macho-González, A. Garcimartín, M. E. López-Oliva, G. Bertocco, F. Naes, S. Bastida, F. J. Sánchez-Muniz and J. Benedí, Food Funct., 2017, 8, 2258
    DOI: 10.1039/C7FO00166E

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