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Issue 3, 2017
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Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice

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Abstract

This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice. Besides, APP also caused the reduction of AST, ALT activities and MDA, CRP, TNF-α levels, and increased the hepatic GSH-Px and SOD activities of the HC-fed mice. Furthermore, the histopathology of the liver by conventional H&E and oil red O staining confirmed the liver steatosis induced by a choline diet and the hepatoprotective effect of APP. The experiment results indicated that the polyphenolic extract from apple peel might be regarded as a preventive and therapeutic product for the amelioration of HC diet-induced vascular dysfunction and hepatic injury.

Graphical abstract: Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice

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Publication details

The article was received on 28 Jan 2017, accepted on 11 Feb 2017 and first published on 13 Feb 2017


Article type: Paper
DOI: 10.1039/C7FO00147A
Citation: Food Funct., 2017,8, 1282-1292
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    Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice

    M. Jia, D. Ren, Y. Nie and X. Yang, Food Funct., 2017, 8, 1282
    DOI: 10.1039/C7FO00147A

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