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Issue 4, 2017
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Dietary fatty acids on aortic root calcification in mice with metabolic syndrome

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Abstract

Metabolic syndrome (MetS) is associated with obesity, dyslipidemia, type 2 diabetes, and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs (HFLCD-MUFAs) or MUFAs plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on vascular calcification by the modulation of the RANKL/RANK/OPG system in the aortic roots of Lepob/obLDLR−/− mice. Animals fed with HFLCD-SFAs had increased weight and a greater atheroma plaque size, calcification, and RANKL/CATHK expression in the aortic root than mice on MUFA-enriched diets, with an increasing OPG expression in the aortic roots of the latter. Our study demonstrates that compared to dietary SFAs, MUFAs from olive oil protect against atherosclerosis by interfering with vascular calcification via the RANKL/RANK/OPG system in the setting of MetS. These findings open opportunities for developing novel nutritional strategies with olive oil as the most important dietary source of MUFAs (notably oleic acid) to prevent cardiovascular complications in MetS.

Graphical abstract: Dietary fatty acids on aortic root calcification in mice with metabolic syndrome

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Publication details

The article was received on 27 Jan 2017, accepted on 23 Feb 2017 and first published on 24 Feb 2017


Article type: Paper
DOI: 10.1039/C7FO00143F
Citation: Food Funct., 2017,8, 1468-1474
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    Dietary fatty acids on aortic root calcification in mice with metabolic syndrome

    M. C. Naranjo, B. Bermudez, I. Garcia, S. Lopez, R. Abia, F. J. G. Muriana and S. Montserrat-de la Paz, Food Funct., 2017, 8, 1468
    DOI: 10.1039/C7FO00143F

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