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Issue 3, 2017
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Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology

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Abstract

This study was aimed at investigating the immunomodulating activity of Hericium erinaceus polysaccharide (HEP) in mice, by assessing splenic lymphocyte proliferation (cell-mediated immunity), serum hemolysin levels (humoral immunity), phagocytic capacity of peritoneal cavity phagocytes (macrophage phagocytosis), and NK cell activity. ELISA of immunoglobulin A (SIgA) in the lamina propria, and western blotting of small intestinal proteins were also performed to gain insight into the mechanism by which HEP affects the intestinal immune system. Here, we report that HEP improves immune function by functionally enhancing cell-mediated and humoral immunity, macrophage phagocytosis, and NK cell activity. In addition, HEP was found to upregulate the secretion of SIgA and activate the MAPK and AKT cellular signaling pathways in the intestine. In conclusion, all these results allow us to postulate that the immunomodulatory effects of HEP are most likely attributed to the effective regulation of intestinal mucosal immune activity.

Graphical abstract: Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology

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Publication details

The article was received on 13 Jan 2017, accepted on 21 Feb 2017, published on 24 Feb 2017 and first published online on 24 Feb 2017


Article type: Paper
DOI: 10.1039/C7FO00071E
Citation: Food Funct., 2017,8, 1020-1027
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    Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology

    X. Sheng, J. Yan, Y. Meng, Y. Kang, Z. Han, G. Tai, Y. Zhou and H. Cheng, Food Funct., 2017, 8, 1020
    DOI: 10.1039/C7FO00071E

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