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Apigenin exhibits protective effects in a mouse model of D-galactose-induced aging via activating the Nrf2 pathway

Abstract

The aim of the present research was to study the protective effects and underlying mechanisms of apigenin on aging mice induced by D-galactose. Firstly, apigenin exhibited a potent antioxidant activity in vitro. Secondly, D-galactose was administered by subcutaneous injection once daily for 8 weeks to establish an aging mouse model to investigate the protective effect of apigenin. We found that apigenin supplementation significantly ameliorated aging-related changes such as behavioral impairment, the decreased organic index, histopathological injury, the increased senescence-associated -galactosidase (SA-gal) activity and advanced glycation end products (AGEs) level. Further data showed that apigenin facilitated the Nrf2 nuclear translocation both in aging mice and normal young mice, and the Nrf2 expression of normal young mice was higher than that of naturally senile mice. In addition, the expressions of Nrf2 downstream gene targets, including HO-1 and NQO1, were also promoted by apigenin administration. Moreover, apigenin also decreased the MDA level and elevated SOD and CAT activities. In conclusion, focusing on the Nrf2 pathway is a suitable strategy to delay the aging process, and apigenin may exert anti-senescent effect process via activating the Nrf2 pathway.

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Publication details

The article was received on 07 Jan 2017, accepted on 16 May 2017 and first published on 18 May 2017


Article type: Paper
DOI: 10.1039/C7FO00037E
Citation: Food Funct., 2017, Accepted Manuscript
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    Apigenin exhibits protective effects in a mouse model of D-galactose-induced aging via activating the Nrf2 pathway

    Y. Sang, F. Zhang, H. Wang, J. Yao, R. Chen, Z. Zhou, K. Yang, Y. Xie, T. Wan and H. Ding, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO00037E

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