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Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of D-galactose induced aging mice

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Abstract

The effects of dietary krill oil on neurocognitive functions and proteomic changes in brain tissues of D-galactose-induced aging mice were evaluated. Dietary krill oil enhanced the neurocognitive functions of aging mice with a significant (P < 0.05) decrease in escape latency and an increase in the number of times of crossing over the hidden platform during the Morris water maze test. Krill oil was also found to protect against oxidative damage, lipid peroxidation and neurodegenerative diseases. Oxidative stress biomarkers of aging mice administered with krill oil showed significant (P < 0.05) improvement with an increase in serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels; there were insignificant changes in the serum malondialdehyde (MDA) level. In terms of proteomic changes, krill oil resulted in upregulation of the Celsr3 and Ppp1r1b gene expression, which contribute to brain development, learning and memory behavior processes. In particular, the Ppp1r1b gene is associated with the inhibition of dopamine releases, which decreases the motivation for learning.

Graphical abstract: Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of d-galactose induced aging mice

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Publication details

The article was received on 25 Dec 2016, accepted on 12 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C6FO01848C
Citation: Food Funct., 2017, Advance Article
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    Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of D-galactose induced aging mice

    L. Cheong, T. Sun, Y. Li, J. Zhou, C. Lu, Y. Li, Z. Huang and X. Su, Food Funct., 2017, Advance Article , DOI: 10.1039/C6FO01848C

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