Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of D-galactose induce aging mice
The effects of dietary krill oil on neurocognitive functions and proteomic changes in brain tissues of D-galactose-induced aging mice was evaluated. Dietary krill oil enhanced neurocognitive functions of aging mice with significant (P<0.05) decreased in escape latency and increased in number of times crossing over the hidden platform during Morris Water Maze test. Krill oil was also found to protect against oxidative damage, lipid peroxidation and neurodegenerative diseases. Oxidative stress biomarkers of aging mice administered with krill oil showed significant (P<0.05) improvement with increased in serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels; and insignificant changes in serum malondialdehyde (MDA) level. In terms of proteomic changes, krill oil resulted in upregulation of Celsr3 and Ppp1r1b genes expression which contribute to brain development, learning and memory behavior processes. In particular, Ppp1r1b gene is associated with inhibition of dopamine releases which decreases motivation for learning.