Jump to main content
Jump to site search


Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of D-galactose induce aging mice

Abstract

The effects of dietary krill oil on neurocognitive functions and proteomic changes in brain tissues of D-galactose-induced aging mice was evaluated. Dietary krill oil enhanced neurocognitive functions of aging mice with significant (P<0.05) decreased in escape latency and increased in number of times crossing over the hidden platform during Morris Water Maze test. Krill oil was also found to protect against oxidative damage, lipid peroxidation and neurodegenerative diseases. Oxidative stress biomarkers of aging mice administered with krill oil showed significant (P<0.05) improvement with increased in serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels; and insignificant changes in serum malondialdehyde (MDA) level. In terms of proteomic changes, krill oil resulted in upregulation of Celsr3 and Ppp1r1b genes expression which contribute to brain development, learning and memory behavior processes. In particular, Ppp1r1b gene is associated with inhibition of dopamine releases which decreases motivation for learning.

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 25 Dec 2016, accepted on 12 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C6FO01848C
Citation: Food Funct., 2017, Accepted Manuscript
  •   Request permissions

    Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of D-galactose induce aging mice

    L. Cheong, T. Sun, Y. Li, J. Zhou, C. Lu, Y. li, Z. Huang and X. Su, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C6FO01848C

Search articles by author