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Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor

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Abstract

The aryl hydrocarbon receptor (AhR) is a pleiotropic nuclear factor that was originally recognized as a “master” of xenobiotic metabolism but demonstrated recently to be a vital regulator of many normal physiological events. Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake. In this review, based on studies conducted over the past decade, we summarized the modes of function of polyphenolic AhR modulators. Furthermore, we made a brief mechanistic synopsis of the pharmacological/therapeutic use of polyphenols as AhR antagonists, selective AhR regulators and dual AhR/ER modulators, and underscored their potential in the prevention/treatment of common human diseases/disorders. Additionally, interesting subjects for further mechanistic investigations on polyphenolic AhR modulators have been provided.

Graphical abstract: Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor

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Publication details

The article was received on 18 Dec 2016, accepted on 24 Feb 2017, published on 27 Feb 2017 and first published online on 27 Feb 2017


Article type: Review Article
DOI: 10.1039/C6FO01810F
Citation: Food Funct., 2017, Advance Article
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    Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor

    Z. Xue, D. Li, W. Yu, Q. Zhang, X. Hou, Y. He and X. Kou, Food Funct., 2017, Advance Article , DOI: 10.1039/C6FO01810F

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