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Impact and Consequences of Polyphenols and Fructo-oligosaccharide Interplay on Gut Microbiota in Rats

Abstract

Both fructo-oligosaccharide (FOS) and polyphenols can be individually and directly transferred to mammal large intestine, and beneficial for human health by reshaping the composition of gut microbiota. The combination impact of polyphenols (quercetin or catechin) and FOS, and its corresponding consequences on gut microbiota in rats were investigated with MiSeq sequencing technique and Bioinformatics. The results showed that different phenolic supplement to FOS displayed distinct impact on host. The supplement of catechin to FOS inhibited Firmicutes and enhanced Bacteroidetes. And the content of each type of short chain fatty acid (SCFA) fluctuated in various groups because different unique bacterial species were survived or inhibited under three conditions. On the other aspects, the supplement of catechin controlled body weight (BW), up-regulated serum leptin, induced more soluble carbohydrates and less soluble polysaccharides in feces, and inhibited or activated some specific genera. The inhibited genera by catechin could be responsible for the degradation of carbohydrates in gut and the activated genera might be keystones for the increment of serum leptin. The effect of consuming FOS and/or polyphenols on the health of hosts needs to be further explored.

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Publication details

The article was received on 11 Dec 2016, accepted on 29 Mar 2017 and first published on 03 Apr 2017


Article type: Paper
DOI: 10.1039/C6FO01783E
Citation: Food Funct., 2017, Accepted Manuscript
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    Impact and Consequences of Polyphenols and Fructo-oligosaccharide Interplay on Gut Microbiota in Rats

    C. Zhen, B. Xue, J. Luo, L. Gao, Y. Wang, S. Ou, S. Li and X. Peng, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C6FO01783E

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