Jump to main content
Jump to site search

Issue 3, 2017
Previous Article Next Article

Potential roles of chemical degradation in the biological activities of curcumin

Author affiliations

Abstract

Substantial pre-clinical and human studies have shown that curcumin, a dietary compound from turmeric, has a variety of health-promoting biological activities. A better understanding of the biochemical mechanisms for the health-promoting effects of curcumin could facilitate the development of effective strategies for disease prevention. Recent studies have shown that in aqueous buffer, curcumin rapidly degrades and leads to formation of various degradation products. In this review, we summarized and discussed the biological activities of chemical degradation products of curcumin, including alkaline hydrolysis products (such as ferulic acid, vanillin, ferulaldehyde, and feruloyl methane), and autoxidation products (such as bicyclopentadione). Though many of these degradation products are biologically active, they are substantially less-active compared to curcumin, supporting that chemical degradation has a limited contribution to the biological activities of curcumin.

Graphical abstract: Potential roles of chemical degradation in the biological activities of curcumin

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 08 Dec 2016, accepted on 13 Jan 2017 and first published on 13 Jan 2017


Article type: Review Article
DOI: 10.1039/C6FO01770C
Citation: Food Funct., 2017,8, 907-914
  •   Request permissions

    Potential roles of chemical degradation in the biological activities of curcumin

    J. Zhu, K. Z. Sanidad, E. Sukamtoh and G. Zhang, Food Funct., 2017, 8, 907
    DOI: 10.1039/C6FO01770C

Search articles by author