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Issue 6, 2017
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Protective effect of Lycium barbarum polysaccharides against cadmium-induced testicular toxicity in male mice

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Abstract

The present study was performed to determine whether Lycium barbarum polysaccharides (LBPs) would protect mice against cadmium (Cd)-induced testicular toxicity. Seventy-two male mice were randomly divided into six groups with twelve mice per group. Four groups were administered orally with cadmium chloride (5.0 mg per kg body weight) for 35 days and treated in combination with LBPs (0, 10.0, 33.3 or 100 mg kg−1) from one week before exposure to Cd until the end of the experiment. The other two groups were administered orally with vehicle or LBP (100 mg kg−1) only. Pretreatment with LBP ameliorated the Cd-induced reduction in the body weights, sperm motility as well as the level of testosterone in serum. Moreover, Cd-induced increase in the abnormal sperms was reduced and effects of Cd on the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were reversed. Histopathological examination further confirmed that the LBPs effectively attenuated Cd-induced degeneration of seminiferous tubules. Thus, LBPs attenuated Cd-induced testicular injury by improving the activity of antioxidant enzymatic activity and lowering the oxidative stress, so it could be a potential auxiliary therapeutic agent for Cd-induced testicular toxicity.

Graphical abstract: Protective effect of Lycium barbarum polysaccharides against cadmium-induced testicular toxicity in male mice

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Publication details

The article was received on 27 Oct 2016, accepted on 16 May 2017 and first published on 17 May 2017


Article type: Paper
DOI: 10.1039/C6FO01583B
Citation: Food Funct., 2017,8, 2322-2330
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    Protective effect of Lycium barbarum polysaccharides against cadmium-induced testicular toxicity in male mice

    L. Zhang, Q. Li, G. Zheng, Y. Chen, M. Huang, L. Zhang and X. Lin, Food Funct., 2017, 8, 2322
    DOI: 10.1039/C6FO01583B

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