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Protective effect of Lycium barbarum polysaccharides against cadmium-induced testicular toxicity in male mice

Abstract

The present study was performed to determine whether Lycium barbarum polysaccharides (LBPs) would protect mice against cadmium (Cd)-induced testicular toxicity. Seventy-two male mice were randomly divided into six groups with twelve mice per group. four groups were administered orally with cadmium chloride (5.0 mg/kg body weight) for 35 days and treated in combination with LBPs (0, 10.0, 33.3 or 100 mg/kg) from one week before exposure to Cd until the end of the experiment. The other two groups were administered orally with vehicle or LBP (100 mg/kg) only. Pretreatment with LBP ameliorated the Cd-induced reduction in the body weights, sperm motility as well as level of testosterone in the serum. Moreover, Cd-induced increase in the abnormal sperms was reduced and effects of Cd on the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were reversed. histopathological examination further confirmed that the LBPs effectively attenuated Cd-induced degeneration of seminiferous tubules. Thus, LBPs attenuated Cd-induced testicular injury by improving the activity of antioxidant enzymatic activity and lowering the oxidative stress, so it could be a potential auxiliary therapeutic agent for Cd-induced testicular toxicity.

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Publication details

The article was received on 27 Oct 2016, accepted on 16 May 2017 and first published on 17 May 2017


Article type: Paper
DOI: 10.1039/C6FO01583B
Citation: Food Funct., 2017, Accepted Manuscript
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    Protective effect of Lycium barbarum polysaccharides against cadmium-induced testicular toxicity in male mice

    L. Zhang, Q. Li, G. Zheng, Y. Chen, M. Huang, L. Zhang and X. Lin, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C6FO01583B

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