Jump to main content
Jump to site search

Issue 3, 2017
Previous Article Next Article

Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice

Author affiliations

Abstract

The protective role of kodo millet whole grain and bran supplementation in diet induced obesity has not been investigated. Here we have studied the role of kodo millet supplementation in age matched Swiss albino mice that were randomly divided into groups and fed their respective diets for 16 weeks. A high fat diet increased weight gain, reduced glucose tolerance, increased serum lipids, altered hepatic and adipocyte gene expression and caused dysbiosis in the intestinal beneficial bacteria. Kodo millet supplementation did not affect weight gain but it improved glucose tolerance and prevented an increase in the serum cholesterol and lipid parameters (P ≤ 0.05), modulated adipogenesis related gene expression, decreased serum IL-6 and LPS levels (P ≤ 0.05), promoted selected beneficial gut bacterial abundances (Lactobacillus sp., Bifidobacteria, Akkermansia and Roseburia spp.) and improved the total short chain fatty acid production (P ≤ 0.05) and acetate levels (P ≤ 0.05) in cecal contents. This study provides evidence that kodo millet supplementation alleviates high-fat diet induced changes and hence can be incorporated as a functional ingredient for the management of obesity.

Graphical abstract: Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 06 Oct 2016, accepted on 24 Jan 2017 and first published on 25 Jan 2017


Article type: Paper
DOI: 10.1039/C6FO01467D
Citation: Food Funct., 2017,8, 1174-1183
  •   Request permissions

    Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice

    S. M. Sarma, P. Khare, S. Jagtap, D. P. Singh, R. K. Baboota, K. Podili, R. K. Boparai, J. Kaur, K. K. Bhutani, M. Bishnoi and K. K. Kondepudi, Food Funct., 2017, 8, 1174
    DOI: 10.1039/C6FO01467D

Search articles by author